https://doi.org/10.1056/NEJMoa2108163. J Med Virol. The Johnson & Johnson vaccine has been associated with thrombosis with thrombocytopenia syndrome (TTS) and Guillain-Barr syndrome (GBS). Efficacy and safety of the mRNA1273 SARSCoV2 vaccine. Headaches 2%. Activate your accountandexplore new ways to earn cash rewards. Between March and August 2021, 54 valid cases (out of 14,080,087 vaccination administrations) were reported, a case-event rate of 3.8 cases per million Johnson & Johnson COVID-19 vaccine doses. Perlman S, Masters PS. JAMA Netw Open. While the majority of those who have been vaccinated have had no adverse reactions after getting their vaccine, some have experienced side-effects which include body aches, headaches and fever . Safety, tolerability, and immunogenicity of an aerosolised adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) in adults: preliminary report of an open-label and randomised phase 1 clinical trial. The background incidence of myocarditis in this age group is 0.2 to 1.9 per million persons [77, 87]. Here is why, starting with the way vaccines work and continuing through strong evidence from vaccine history and the even stronger evidence from the responses of people who have received COVID-19 vaccines worldwide over the past six months. A simple and perhaps simplistic conversion is to multiply the rate per dose by the number of doses. PubMed Central Of the four vaccines made in China, CoronoVac and Sinopharm are the most common, followed by CanSinBio and another produced jointly by Anhui Zhifei Longcom Biopharmaceutical and the Chinese Academy of Sciences. 2005;23:121. That's because your immune system responds to vaccines through a process called "controlled inflammation," Dr. Colleen Kelley,an associate professor of medicine at Emory University School of Medicine,told USA Today in January. J Infect Dis. (Photo by: Steve Wood)But Goepfert says we already know enough to be confident the COVID vaccines are safe. Accessed 6 Jan 2022, U.S. Food and Drug Administration. https://www.fda.gov/news-events/press-announcements/fda-issues-emergency-use-authorization-third-covid-19-vaccine, CDCThe Janssen COVID-19 Vaccines Local Reactions, Systemic Reactions, Adverse Events, and Serious Adverse Events.Accessed February 27th, 2022 from. That data is already in, says Paul Goepfert, M.D., and vaccine experts are confident that there won't be long-term side effects. 2016;64(6):140315. Allergic reactions including anaphylaxis after receipt of the first dose of Moderna COVID-19 vaccine - United States, December 21, 2020-January 10, 2021. Accessed 22 Mar 2020. Don't miss: The best credit cards for building credit. Haq HN, Khan H, Chaudhry H, Nimmala S, Demidovich J, Papudesi BN, Potluri SD. Circulation. You can email the site owner to let them know you were blocked. The combination therapy uses either 0.9% saline or 5% dextrose in water as its diluent [35]. PubMed https://doi.org/10.1101/2021.05.07.21256652, Sadoff J, Le Gars M, Shukarev G, Heerwegh D, et al. The adverse effects from vaccines against COVID-19 resemble those from previous vaccines in type and frequency, including a slight increase in the risk of myocarditis for young males. People who had severe illness with COVID-19 might experience organ damage affecting the heart, kidneys, skin and brain. 1953;98(6):64156. The https:// ensures that you are connecting to the This site needs JavaScript to work properly. Extracellular RNA mediates endothelial-cell permeability via vascular endothelial growth factor. the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in https://doi.org/10.1016/j.jconrel.2021.03.043. Hundt MA, Deng Y, Ciarleglio MM, Nathanson MH, et al. Khiali S, Khani E, Entezari-Maleki T. A comprehensive review of tocilizumab in COVID-19 acute respiratory distress syndrome. 2021;21(6):38293. You might run a fever and experience body aches, headaches and tiredness for a day or two. https://doi.org/10.1042/BJ20041021. In a phase I trial of 130 participants in Wuhan, China, within 7days after vaccination, adverse events occurred in approximately 70% of those who received the vaccine intramuscularly and 65% of those who received it via nebulizer. The general risks associated with plasma transfusion are acute lung injury, circulatory overload, allergic/anaphylactic reactions, transmission of infections, febrile hemolytic and non-hemolytic transfusion reactions, and RBC alloimmunization. On December 18th, 2020, the Moderna COVID-19 Vaccine (mRNA-1273) became the second vaccine to receive EUA by the FDA to prevent COVID-19 infection in patients 18years of age and older [64]. MAbs. There should be confidence in that. https://doi.org/10.1016/S0140-6736(21)00676-0. Headlines wont help you lose weight. https://doi.org/10.15585/mmwr.mm7002e1. The only vaccine program that might compare with the scale and speed of the COVID rollout is the original oral polio vaccine in the 1950s, Goepfert says. You need 2 doses for stronger and longer-lasting protection. Castells MC, Phillips EJ. Vaccines prevent progression for a larger part of the population. In the last 2years, the monoclonal antibodies, protein vaccines, and more mRNA vaccines emerged. Accessed 6 Jan 2022. Rev Med Inst Mex Seguro Soc. Accessibility Mounting evidence suggests Sputnik COVID vaccine is safe and effective. In the days following COVID-19 vaccination, your immune system responds to the vaccine. Maintaining safety with SARS-CoV-2 vaccines. The FDA approved the dose of 600mg casirivimab and 600mg imdevimab [14]. The mum-of-two, from Tysoe, Stratford-upon-Avon, went to her GP after finding a lump but was told there was "nothing to worry about" and it might've been a side effect of her Covid vaccine. 3 things to know, New B Well UAB app now offers resources to employees, Caring for patients, Blazers through COVID-19, Blazer-created mental health app puts wellness in student hands, Resiliency training gives all students the tools to bounce back, Get a discounted rate on personal training certification through URec partnership, Ombuds offers a collaborative approach for resolving conflict at work, Employees finding help for anxiety in myStrength app, EACC to increase free sessions to 15 per year beginning Nov. 1, Savings can buy peace of mind. sharing sensitive information, make sure youre on a federal You can also search for this author in People have had varying reactions to the COVID-19 shot, which experts say is normal. Accessed 12 Dec2022. It is a trimeric glycosylated transmembrane complex embedded in the lipid bilayer that surrounds the viral genome. Vaccines, given in one- or two-shot doses, are very different from medicines that people take every day, potentially for years. Sotrovimab binds to a region in S2 that helps the host and virus membrane fuse. Vaccine 2019; 37: 2494-2501. In: Howley PM, Knipe DM, editors. The action you just performed triggered the security solution. https://doi.org/10.1056/NEJMoa2102685. Accessed 22 Mar 2022, National Center for Immunization and Respiratory Diseases (U.S.).Division of Viral Diseases, Moderna COVID-19 Vaccine (also known as Spikevax) Overview and Safety. Symptoms may include: tightness, heaviness, discomfort or pain in your chest or neck difficulty breathing or catching your breath feeling faint or dizzy or light-headed fluttering, racing or pounding heart, or feeling like it is 'skipping beats'. Most reactions were mild (grade 1) and resolved within 48h. The authors reported no serious adverse events within 28days of vaccination. The patient improved after 2 doses of 0.3mg intramuscular epinephrine. After getting vaccinated for COVID-19, you might experience some temporary symptoms similar to those you might notice when you get a flu shot, such as a sore, swollen arm where you got the shot. The immune system then creates antibodies against it which is controlled inflammation and can remember how to trigger an immune response if exposed to the virus in the future. Gupta A, Gonzalez-Rojas Y, Juarez E, Crespo Casal M, et al. 2021;10(333):51120. Cytokine storm refers to fevers, chills, myalgias, and acute lung injury resulting from direct activation of various immunocompetent cells including macrophages, monocytes, lymphocytes, and natural killers (NK) cells. https://doi.org/10.1161/CIRCULATIONAHA.121.055891. FOIA https://doi.org/10.1148/radiol.2021211766. Both vaccines deliver mRNA encoding the entire S protein with 2 equal proline substitutions for stability. Efforts to develop therapeutics have led to innovations such as mRNA vaccines and oral antivirals. We also included each vaccines application for Emergency Use Authorization by the FDA. ; COVE Study Group . Both patient/recipient information and healthcare professional fact sheets for each of these drugs were manually searched to find their orofacial adverse effects. Convalescent plasma has side effects like monoclonal antibodies, but with more infusion reactions and less efficacy. After the EUA, bamlanivimab 700mg and etesevimab 1400mg have been administered to roughly 800 patients across all clinical trials. They were initially identified from convalescent plasma obtained from COVID-19 survivors. Infusion reactions were most commonly pyrexia, chills, dizziness, and dyspnea. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Background rates of five thrombosis with thrombocytopenia syndromes of special interest for COVID-19 vaccine safety surveillance: Incidence between 2017 and 2019 and patient profiles from 38.6 million people in six European countries. Chills, headache, and fatigue after a shot are perfectly normal. Eur Rev Med Pharmacol Sci. The increased incidence of myocarditis in young adult men is not unique to mRNA vaccines for COVID. A prospective study of the incidence of myocarditis/pericarditis and new onset cardiac symptoms following smallpox and influenza vaccination.PLoS One. 2021;148(3):e2021052478. Please enable it to take advantage of the complete set of features! Bookshelf 2021;325(15):15625. Lets talk about lipid nanoparticles. Nogrady B. Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page. Common (not rare) side effects of COVID-19 vaccine. Fact sheet for healthcare providers Emergency Use Authorization (EUA) for Sotrovimab. Seven patients who received sotrovimab (2%) reported serious adverse events as opposed to 27 patients (6%) in the placebo group. J Hepatol. Developing covid19 vaccines at pandemic speed. Throughout Wellness Week Oct. 17-21, employees and students from across UAB and UAB Medicine shared dozens of photos and videos that represent what wellness means to them. https://doi.org/10.1002/jmv.27109, Shavit R, Maoz-Segal R, Iancovici-Kidon M, Offengenden I, et al. INO-4800 is a DNA vaccine that encodes the SARS-CoV-2 S protein. Click to reveal How COVID-19 vaccines are developed, tested and approved. Advisory Committee on Immunization Practices January 5, 2022. Most reported myocarditis cases resolved either spontaneously or with the standard interventions for myocarditis. On July 12, 2021, the FDAannounced that in rare cases(100 reports out of 12.8 million shots given in the United States), the J&J vaccine is associated with Guillan-Barr syndrome. https://doi.org/10.15585/mmwr.mm7004e1. Yes, you can take OTC pain meds after getting the Covid vaccine, says CDC plus other tips for dealing with side effects. Sci Immunol. Antibody toxicity can arise from an expected effect on the target, an immunologic response to the antibody, or from off-target binding. ", The long-term side effects of COVID infection are a major concern. What makes Goepfert think that scientists wont discover previously unsuspected problems caused by COVID vaccines in the years ahead? 2022;146(10):74354. White spots on your tongue can be a sign of Covid or a vaccine side effect, says expert WHITE spots on the tongue - it's usually nothing serious. The B cells produce antibodies to the Spike protein, which they now perceive as an antigen. Rosas IO, Bru N, Waters M, Go RC, et al. Data on etesevimab are limited to only trials involving etesevimab and bamlanivimab. Internal and external forces are pushing us all to expand our waistlines. 2015;211(1):8090. We have all seen billboards and TV infomercials from law firms seeking people harmed by diet drugs or acid-reflux medicines for class-action lawsuits. Ad26-vector vaccines are generally considered safe and effective constructs, having been used for RSV, Zika, and HPV vaccines [48]. Questions about the $400 vaccine incentive payments? ulcers, vesicles, blisters, plaque, mouth odour, bleeding gum, burning gingiva, etc) following receiving the COVID-19 vaccine. Engler RJ, Nelson MR, Collins LC Jr, Spooner C, et al. The most frequent were diarrhea (2%) and rash (1%). N Engl J Med. A smaller number of cases have occurred with Johnson & Johnson's vaccine as well, Goepfert said. Abnormal liver tests in COVID-19: a retrospective observational cohort study of 1,827 patients in a major U.S. hospital network. Combination therapy is approved under EUA for pediatric patients less than 2years of age who are hospitalized due to COVID. 2021;598(7881):3989. CoronaVac and Sinopharm vaccines are based on an inactivated form of SARS-CoV-2. Clipboard, Search History, and several other advanced features are temporarily unavailable. https://doi.org/10.1001/jamanetworkopen.2021.30800. Oster ME, Shay DK, Su JR, Gee J, et al. A new study has found that certain vaccine side effects are more common in people who have already . doi: 10.1371/journal.pone.0272876. Eighteen of the 23 were also receiving convalescent plasma, remdesivir, tocilizumab, hydroxychloroquine, or sarilumab [19]. That said, in some cases, the side effects can interfere with your ability to go about your daily life, so you may want to plan accordingly. 2021;144(6):47184. Google Scholar. Radiology. 2021 Aug 5;10(8):752. doi: 10.3390/biology10080752. 2022 Aug 17;19(16):10228. doi: 10.3390/ijerph191610228. In the case of the two mRNA COVID-19 vaccines, well over 90% of people immunized developed the protective adaptive immune response while fewer than 50% developed any side effects, and most were mild. Int J Cardiol. There was heterogeneity in the acknowledgement of vaccine-related adverse events in North America compared with Europe. 2021;325(7):63244. As of this writing, the Moderna, Pfizer, Johnson & Johnson, and Novavax (a protein vaccine not discussed here) are approved by the FDA. No cases of antibody-dependent enhancement or vaccine-enhanced disease were confirmed. In June 2021 the FDA issued an EUA for tocilizumab in patients 2years or older hospitalized with COVID-19 and requiring supplemental oxygen who were also receiving corticosteroids [29]. The chances of any of these side effects occurring after vaccination differ according to the specific vaccine. Accessed 22 Mar 2022. There were 3 reported cases of Bells palsy (one a serious adverse event) in the vaccine group and 1 in the placebo group. Vaxart said the vaccine generated a type of T-cell responsible . This "Covid arm" rash can be red, itchy, swollen, or painful. 2021;4:100083. https://doi.org/10.1016/j.jtauto.2021.100083. Tubes of blood drawn from Brianne Dressen, who suffered complications after a coronavirus vaccine, are part of a National Institutes of Health study. In 48 patients in Wuhan, China, IL-6 levels were correlated with the degree of SARS-CoV-2 viremia and an independent predictor of mortality [24]. That is not to say that there have never been safety issues with vaccines. N Engl J Med. Myocarditis following COVID-19 vaccination. CanSinBio is a DNA vaccine like Johnson & Johnson. Get your workspace set up right and learn the risks of cumulative trauma with UABs online Office Ergonomics Awareness Course. But the rare side effects identified with COVID vaccines have to be weighed against the known, higher risks from contracting COVID, Goepfert says. https://doi.org/10.4161/mabs.3.6.17922, Pilot clinical trial in China to test UBC researchers findings as a targeted therapy for COVID-19 - UBC Faculty of Medicine. Article It may involve the vaccine excipient. Myocarditis following immunization with mRNA COVID-19 vaccines in members of the US military. Myocarditis after BNT162b2 mRNA vaccine against Covid-19 in Israel. Think eating healthier is too expensive to try? Globally, there are inconsistencies in the description of adverse effects presenting in the orofacial region of the COVID-19 vaccines BNT162b2 and mRNA-1273. Vaccines (Basel). The BLAZE-1 clinical trial also evaluated the combination of bamlanivimab and etesevimab, which did reduce viral load. Also good to know: More people experience side effects from the second of the two doses. blurred vision, nausea and vomiting difficulty with your speech, weakness, drowsiness or seizures new, unexplained pinprick bruising or bleeding shortness of breath, chest pain, leg swelling or. A 90% decrease in risk of infections and 94% effectiveness against hospitalization for the Pfizer and Moderna vaccines is fantastic, he said. In a Phase 1 trial of healthy adults in China, the incidence of adverse effects ranged from 29 to 38%, depending on dose used, 3g or 6g, compared to 8% of those who received placebo. "The vaccine side effects from COVID-19 vaccines are generally the same as with other vaccines except for the rare episodes of myocarditis in young men which can be circumvented by increasing the . 2022 Jan;22(1):64-72. doi: 10.1016/S1473-3099(21)00451-5. Lancet Infect Dis. government site. J Community Health. MeSH After intramuscular injection, antigen presenting cells (APCs) internalize the LNPs and translate the mRNA into the S protein. A Division of NBC Universal, What Covid-19 health disparities mean to six black medical professionals, How this 39-year-old earns $26,000 a year in California. Nature. That is not to say that there have never been safety issues with vaccines. People who get a COVID-19 vaccine may feel pain, redness and swelling in the location of the shot, according to the CDC, adding that throughout the body people may feel fatigue, muscle pain, chills, fever, headaches and nausea. ISSN 1476-5373 (online) ), More recently, an even more rare side effect myocarditis, or inflammation of the heart muscle has been reported in people receiving Pfizer and Moderna COVID-19 vaccines. Immune Netw. Fact Sheet for Health Care Providers Emergency Use Authorization (EUA) of REGEN-COV (casirivimab and imdevimab).2021. https://www.fda.gov/media/145611/download. 2021 John Wiley & Sons A/S. 2022;327(4):33140. But you can overcome them by making smart choices that work in your life, says UAB health behavior expert Kathryn Kaiser, Ph.D. Heres how. The CCL5/CCR5 axis promotes interleukin-6 production in human synovial fibroblasts. Lancet. Shimabukuro TT, Cole M, Su JR. Reports of anaphylaxis after receipt of mRNA COVID-19 vaccines in the US-December 14, 2020-January 18, 2021. Zare H, Rezapour H, Mahmoodzadeh S, Fereidouni M. Prevalence of COVID-19 vaccines (Sputnik V, AZD-1222, and Covaxin) side effects among healthcare workers in Birjand city, Iran. Dr. Sumon Chakrabarti empathizes with other Canadians who have reported common side effects after receiving their COVID-19 vaccines. Pharmacoepidemiol Drug Saf. VAERS surveys a larger group than do clinical trials, allowing VAERS to detect rarer events or events in populations the clinical trials did not study. Try these four Rs to break free. Here's what you should know. 2021;325(15):15351544. 2021;4(10):e2130800. Springer Nature or its licensor (e.g. Accessed 26 Feb 2022 from https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2022-01-05/02-covid-su-508.pdf. Epub 2020 Jul 23. Caregivers should ask children how they are feeling. 2021;11:100241. https://doi.org/10.1016/j.lanepe.2021.100241, Jarynowski A, Semenov A, Kamiski M, Belik V. Mild adverse events of Sputnik V vaccine in Russia: social media content analysis of telegram via deep learning. official website and that any information you provide is encrypted Early treatment for Covid-19 with SARS-CoV-2 neutralizing antibody sotrovimab. Clinical considerations: myocarditis and pericarditis after receipt of mRNA COVID-19 vaccines among adolescents and young adults. UABs AWARE program provides confidential disability-management services when an employees job is affected by a physical, mental or emotional impairment. According to the CDC, the side effects of the Covid vaccine should go away in a few days. 2020 Dec 1;16(12):3061-3073. doi: 10.1080/21645515.2020.1830683. 2022;18(1):2002083. https://doi.org/10.1080/21645515.2021.2002083. https://doi.org/10.1038/s41415-021-2615-x, DOI: https://doi.org/10.1038/s41415-021-2615-x. JAMA. Nat Rev Mater. JAMA. There was no description of the rash nor any discussion of infusion-related reactions. Fields virology: emerging viruses. Reported side effects of COVID-19 vaccines have mostly been mild to moderate and have lasted no longer thana few days. Available at: https://stars.library.ucf.edu/cgi/viewcontent.cgi?article=1306&context=honorstheses (accessed December 2020). On December 11, 2020, the COVID-19 Pfizer-BioNTech (BNT162b2) vaccine became the first to receive EUA by the US Food and Drug Administration (FDA) for the prevention of COVID-19 in patients 16years and older [60], later extending approval for children 5years and older [61, 62]. "We don't know why that is, how long these symptoms will last or if there are effective ways to treat them. The highest incidence occurred in those ages 30 to 39 (10.6 cases per million vaccine doses), followed by those 40 to 49years of age (9.0 cases per million vaccine doses). There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. The preprint reported that nearly 1 in 2 recipients experienced local site irritation, pain, or swelling, but reported no serious adverse events. Safety and efficacy of the BNT162b2 mRNA Covid19 vaccine. AusVaxSafety is tracking whether people experience side effects after COVID-19 vaccines. 2021;373:n912. Try these experiments instead. It is administered to patients who have contracted the disease and are at high risk for deterioration without intervention. Up to 10 percent of people who have COVIDexperience side effectssuch as difficulty thinking, pain, tiredness, loss of taste and depression. Other viral infections are associated . Covid vaccines come with some side effects, which is a sign that your . We're more familiar now with the possible side effects from the COVID-19 vaccine interacting with our immune system. Lancet. LNPs, originally designed to ferry xenobiotics, allow the mRNA to infect (enter) the cell, which it cannot do on its own. https://doi.org/10.4161/mabs.2.3.11782. 2021 Jan;22(2):70-71. doi: 10.1038/s41432-021-0178-y. [Bell's Palsy Secondary to COVID-19 Vaccine Pfizer: Case report]. 81.7.11.205 The Johnson & Johnson COVID-19 Vaccine (Ad26.COV2.S) is the third vaccine to receive EUA by the FDA for the prevention of COVID-19 in patients 18years of age and older [49]. 2007;104(15):638893. Both use polyethylene glycol (PEG) 2000 to stabilize the lipid nanoparticles [91, 92]. The speed of development and effectiveness of vaccines has been matched by public resistance to receiving the vaccine and misinformation [3], mostly over-emphasizing the adverse effects of the vaccine and downplaying the risks of untreated COVID-19, a calculus that also changes with each variant [4]. In patients 30years or younger who were ultimately diagnosed with vaccine-associated myocarditis, 89% reported chest pain (including pressure or discomfort), 98% had an elevated troponin level, and 72% had an abnormal EKG. The FDA authorized dose for the combination for adults is bamlanivimab 700mg and etesevimab 1400mg, not the 2800mg and 2800mg used in the studies discussed above. Our description of substances and their effects is not exhaustive and presents our knowledge as of June 2022. 2007;110(7):245765. https://doi.org/10.1056/NEJMra2035343. Sputnik Light is the first dose of Sputnik V. It was created to facilitate distribution to countries with widespread infection that need to quickly vaccinate. A study of self-reports from 503 healthcare workers in Birjand, Iran, found muscle pain, fatigue, and fever to be the most common adverse events after the first dose of Sputnik V [115], occurring in 48% of those who received the vaccine, although the study did not report the frequency of each symptom individually. Although adverse events may occur after being vaccinated with a COVID-19 vaccine, they are not necessarily related to the vaccine. EClinicalMedicine. The most reported symptoms after the first and second doses were pain at the injection site (83.7% and 88.7%, respectively), fatigue (37.2% and 65.2%), headache (32.7% and 58.5%), muscle pain (22.7% and 57.6%), and arthralgia (16.6% and 42.6%) [65]. An analysis of self-reports from 3236 Iranian healthcare workers in Mazandaran, Iran, who were vaccinated with Sputnik V (mean age 39.32, 61.2% women) reported pain (56.9%), fatigue (50.9%), body pain (43.9%), headache (35.7%), fever (32.9%), joint pain (30.3%), chills (29.8%), and drowsiness (20.3%) as the most common side effects [114]. Thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination. 2021;93(10):60276029. https://doi.org/10.1016/S1473-3099(21)00751-9. Lancet Infect Dis. Thus, once inside the cell, the LNP and mRNA dissociate, leaving mRNA transcript in the APC cytoplasm that is indistinguishable from the APCs own mRNA. 2021;4(8):e2122255. Sputnik Light can be stored at 28C, compared to Sputnik V, which must be stored at below 18C. 3. Efficacy and safety of the RBD-dimer-based Covid-19 vaccine ZF2001 in adults. Google Scholar. No cases of myocarditis or pulmonary embolus were reported. Those who received the vaccine reported more adverse events than those who received the placebo, usually lymphadenopathy in the arm and neck. 2015;10(3):e0118283. Tarakji B, Umair A, Alakeel R et al. The certification, normally $1,500, is $650 for students and $750 for nonstudents. Those individuals should continue as normal, but check with their doctor for additional guidance before getting the vaccine, as there could be ramifications for skipping medication. https://doi.org/10.1126/sciimmunol.aaf7643, Stephenson KE, Le Gars M, Sadoff J, de Groot AM, et al. Pain at the injection site was the most frequent local adverse event (157 [2.4%] vs 40 [1.1%], respectively) [103]. Bell's palsy following vaccination with mRNA (BNT162b2) and inactivated (CoronaVac) SARS-CoV-2 vaccines: a case series and nested case-control study.
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